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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8795


    Title: Low-dose memantine attenuated methadone dose in opioid-dependent patients: A 12-week double-blind randomized controlled trial
    Authors: Lee, SY;Chen, SL;Chang, YH;Chen, PS;Huang, SY;Tzeng, NS;Wang, LJ;Lee, IH;Wang, TY;Chen, KC;Yang, YK;Hong, JS;Lu, RB
    Contributors: Center for Neuropsychiatric Research
    Abstract: Low-dose memantine might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. We investigated whether add-on memantine reduced cytokine levels and benefitted patients with opioid dependence undergoing methadone maintenance therapy (MMT) in a randomized, double-blind, controlled 12-week study. Patients were randomly assigned to a group: Memantine (5 mg/day) (n = 53) or Placebo (n = 75). The methadone dose required and retention in treatment were monitored. Plasma tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), interleukin (IL)-6, IL-8, transforming growth factor (TGF)-beta1, and brain-derived neurotrophic factor (BDNF) levels were examined during weeks 0, 1, 4, 8, and 12. General linear mixed models were used to examine therapeutic effect. After 12 weeks, Memantine-group required a somewhat lower methadone dose than did Placebo-group (P = 0.039). They also had significantly lower plasma TNF-alpha and significantly higher TGF-beta1 levels. We provide evidence of the benefit of add-on memantine in opioid dependent patients undergoing MMT.
    Date: 2015-05-19
    Relation: Scientific Reports. 2015 May 19;5:Article number 10140.
    Link to: http://dx.doi.org/10.1038/srep10140
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000355294400001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930212138
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