 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12145/12927 (94%)
Visitors : 906124
Online Users : 731
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/8793
|
| Title: | Risk factors and outcome for colistin resistant acinetobacter nosocomialis bacteraemia in patients without previous colistin exposure |
| Authors: | Wang, YC;Lee, YT;Yang, YS;Chen, CT;Chiu, CH;Yin, T;Kuo, SC;Chen, TL;Lin, JC;Wang, F;Fung, CP;Chang, FY |
| Contributors: | Division of Infectious Diseases |
| Abstract: | The clinical characteristics of patients with colistin-resistant A. baumannii have been documented, but those of other Acinetobacter species remain unknown. Previous exposure of colistin has been documented to be associated with the emergence of colistin resistance, but may be not the only predisposing factor. In the current study, we highlight the risk and outcome of patients without previous exposure to colistin who acquired colistin-resistant Acinetobacter nosocomialis (ColRAN) bacteraemia. This 11-year single-center retrospective study analyzed 58 patients with ColRAN bacteraemia and 213 patients with colistin-susceptible A. nosocomialis (ColSAN) bacteraemia. Antimicrobial susceptibilities were determined by an agar dilution method. The clonal relationship of ColRAN isolates was determined by pulse-field gel electrophoresis. A conjugation mating-out assay was conducted to delineate potential transfer of colistin resistance genes. Multivariable analysis was performed to evaluate the risk factors for ColRAN bacteraemia. Chronic obstructive pulmonary disease (COPD) was independently associated with ColRAN bacteraemia (odds ratio, 3.04; 95% confidence interval, 1.45-6.37, p 0.003). Patients with ColRAN had higher APACHE II scores, but the two groups had no significant differences in 14-day (10.3% vs. 10.3%) or 28-day mortality (15.5% vs. 15.0%). ColRAN isolates had greater resistance to most antimicrobial agents than ColSAN, except ciprofloxacin (0% vs. 6.6%). There were 16 different ColRAN pulsotypes and two major clones were found. Colistin resistance did not transfer to colistin-susceptible A. baumannii or A. nosocomialis. These results highlighted COPD is an independent risk factor for acquisition of ColRAN bacteraemia. The mortality rates were similar between patients with ColRAN and ColSAN bacteraemia. |
| Date: | 2015-08 |
| Relation: | Clinical Microbiology and Infection. 2015 Aug;21(8):758-764. |
| Link to: | http://dx.doi.org/10.1016/j.cmi.2015.05.005 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1198-743X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000358269200008 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84937521995 |
| Appears in Collections: | [郭書辰] 期刊論文
|
Files in This Item:
There are no files associated with this item.
|
All items in NHRI are protected by copyright, with all rights reserved.
|
