國家衛生研究院 NHRI:Item 3990099045/8786
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8786


    Title: The heart protection effect of alcalase potato protein hydrolysate is through IGF1R-PI3K-Akt compensatory reactivation in aging rats on high fat diets
    Authors: Hu, WS;Ting, WJ;Chiang, WD;Pai, P;Yeh, YL;Chang, CH;Lin, WT;Huang, CY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: The prevalence of obesity is high in older adults. Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might have greater benefits and be more economical than hypolipidemic drugs. In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day). APPH treatments reduced serum triacylglycerol (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels to the normal levels expressed in the control group. Additionally, the IGF1R-PI3K-Akt survival pathway was reactivated, and Fas-FADD (Fas-associated death domain) induced apoptosis was inhibited by APPH treatments (15 and 45 mg/kg/day) in HFD aging rat hearts. APPH (75 mg/kg/day) rather than probucol (500 mg/kg/day) treatment could reduce serum lipids without affecting HDL expression. The heart protective effect of APPH in aging rats with hyperlipidemia was through lowering serum lipids and enhancing the activation of the compensatory IGF1R-PI3K-Akt survival pathway.
    Date: 2015-05-05
    Relation: International Journal of Molecular Sciences. 2015 May 5;16(5):10158-10172.
    Link to: http://dx.doi.org/10.3390/ijms160510158
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000356241400062
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929340105
    Appears in Collections:[Chung-Ho Chang] Periodical Articles

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