國家衛生研究院 NHRI:Item 3990099045/8761
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    题名: The association between medical history and breast cancer risk: A nationwide population-based case-control study using claim data
    作者: Chuang, SC;Wu, GJ;Lu, YS;Lin, CH;Hsiung, CA
    贡献者: Division of Biostatistics and Bioinformatics;Division of Health Policy Translation
    摘要: Introduction: It is suggested that chronic disease may be associated with increased cancer risk due to common risk factors, treatments to the prior conditions, or other unknown mechanisms. We evaluated the associations between prior medical conditions and subsequent breast cancer risk using the claim data from the Taiwan National Health Insurance (NHI) program. Material and Method: A matched case-control study was conducted using the NHI 1,000,000 random sample dataset. A list of medical conditions based on literature review was retrieved for each case and control. The odds ratios (OR) and 95% confidence intervals (CI) of the association between medical conditions and breast cancer risk were estimated using conditional logistic regression and adjusted for occupation and number of breast cancer screening. The associations were estimated for younger (<50 years old) and older subjects, separately. Results: Prior breast diseases, hypertensive diseases, and endometriosis were associated with increased breast cancer risk in both age groups. Thyroid diseases were associated with breast cancer in the younger (OR=1.32, 95% CI=1.04-1.66) but not in the older group (OR=1.02, 95% CI=0.82-1.27). On the other hand, metabolic syndrome, particularly the disorders involved lipid metabolism, was associated with breast cancer only in the older group (OR=1.24, 95% CI=1.04-1.49). Conclusion: Our analyses support results from previous studies that prior breast diseases and endometriosis were associated with subsequent breast cancer at all ages, thyroid diseases were associated with premenopausal, and metabolic syndrome were associated with postmenopausal breast cancer.
    日期: 2014-10
    關聯: Cancer Research. 2014 Oct;74(19 Suppl.):Abstract No. 270.
    Link to: http://dx.doi.org/10.1158/1538-7445.am2014-270
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000349906903451
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