國家衛生研究院 NHRI:Item 3990099045/8671
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    题名: Recombinant lipoproteins as novel vaccines with intrinsic adjuvant
    作者: Chong, P;Huang, JH;Leng, CH;Liu, SJ;Chen, HW
    贡献者: Division of Vaccine Research and Development
    摘要: A core platform technology for high production of recombinant lipoproteins with built-in immunostimulator for novel subunit vaccine development has been established. This platform technology has the following advantages: (1) easily convert antigen into lipidated recombinant protein using a fusion sequence containing lipobox and express high level (50-150. mg/L) in Escherichia coli; (2) a robust high-yield up- and downstream bioprocess for lipoprotein production is successfully developed to devoid endotoxin contamination; (3) the lipid moiety of recombinant lipoproteins, which is identical to that of bacterial lipoproteins is recognized as danger signals by the immune system (Toll-like receptor 2 agonist), so both innate and adaptive immune responses can be induced by lipoproteins; and (4) successfully demonstrate the feasibility and safety of this core platform technology in meningococcal group B subunit vaccine, dengue subunit vaccine, novel subunit vaccine against Clostridium difficile-associated diseases, and HPV-based immunotherapeutic vaccines in animal model studies.
    日期: 2015-06
    關聯: Advances in Protein Chemistry and Structural Biology. 2015 Jun;99:55-74.
    Link to: http://dx.doi.org/10.1016/bs.apcsb.2015.03.003
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000405228600004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84946491921
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