Highly branched poly(beta-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect[registered sign], for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.
Date:
2015-05
Relation:
Chemical Communications. 2015 May;51(40):8473-8476.
