國家衛生研究院 NHRI:Item 3990099045/8611
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    题名: Toll-like receptor polymorphisms as risk factor for Clostridium difficile colonization and infection
    作者: Hung, YP;Lin, HJ;Tsai, PJ;Ko, WC
    贡献者: Division of Infectious Diseases
    摘要: Purpose: Patients with TLR4 polymorphisms were more likely to have intestinal infections due to gram-negative organisms. This study is to investigate the impact of toll-like receptor (TLR) polymorphism on Clostridium difficile colonization and infection. Methods: Adults admitted to medical wards in a district hospital between January 2011 and January 2013 were enrolled, and those with a history of colectomy, C. difficile fecal colonization or infection or receipt of either metronidazole or oral vancomycin within 3 months, were excluded. Stools collected within 48 hours after admission and every week during hospitalization were cultured for C. difficile. Results: Among the 445 enrolled patients, 92 (20.7%) developed toxic C. difficile colonization (tCdC) and 21 (4.7) developed C. difficile associated diarrhea (CDAD). The mortality rate was 13.7 %. There was no difference in age, gender, receipt of antibiotics or proton-pump inhibitor or underlying disease (including diabetes mellitus, hypertension, old stroke, chronic kidney disease or having malignancy) among patients with different TLR4 rs1927914 polymorphism (GG, GA or AA type). We found TLR4 rs1927914 polymorphism A-carrier (including GA and AA) was associated with developing CDAD compared to GG type (4.9 and 5.2 vs 2.9 %, P = 0.02) but not correlated with tCDC or mortality. Other TLR4 polymorphism (rs10983755) and three TLR2 SNPs (rs1898830, rs3804099, and rs7656411) were also analyzed but not related to CDAD or tCDC. Conclusions: The incidence of CDAD is highest in patients with the TLR4 rs1927914 polymorphism GA and AA genotype.
    日期: 2015-04
    關聯: Journal of Microbiology, Immunology and Infection. 2015 Apr;48(2, Suppl. 1):S30.
    Link to: http://dx.doi.org/10.1016/j.jmii.2015.02.035
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
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