國家衛生研究院 NHRI:Item 3990099045/8554

NHRI > National Institute of Infectious Diseases and Vaccinology > Wang-Chou Sung > Periodical Articles > Item 3990099045/8554

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8554

Title:	Screening and profiling stilbene-type natural products with angiotensin-converting enzyme inhibitory activity from Ampelopsis brevipedunculata var. hancei (Planch.) Rehder
Authors:	Su, PS;Doerksen, RJ;Chen, SH;Sung, WC;Juan, CC;Rawendra, RDS;Chen, CR;Li, JW;Aisha;Huang, TC;Liao, MH;Chang, CI;Hsu, JL
Contributors:	Division of Vaccine Research and Development
Abstract:	In this study, we screened 10 resveratrol derivatives isolated from Ampelopsis brevipedunculata var. hancei (Planch.) Rehder (ABH) for angiotensin I converting enzyme (ACE) inhibitory (ACEI) activity. Among these compounds, (+)-hopeaphenol and (+)-vitisin A showed the lowest IC50 values (?1.5 μM) toward ACE. In addition, the compounds’ abundances and distributions in ABH were profiled using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Interestingly, trimers and tetramers of resveratrol were mainly obtained from the bark of ABH when 90% ethanol was used for extraction. This result implies that the antihypertension effect of ABH extract may be mainly contributed by (+)-hopeaphenol (F1) and (+)-vitisin A (F2) in the ABH bark due to their remarkable ACE inhibitions. Moreover, the sizes and structures of these compounds were further correlated to their affinities toward ACE using molecular docking calculations. The results showed that resveratrol tetramers interact with ACE more favorably than other smaller oligomers.
Date:	2015-04-10
Relation:	Journal of Pharmaceutical and Biomedical Analysis. 2015 Apr 10;108:70-77.
Link to:	http://dx.doi.org/10.1016/j.jpba.2015.01.053
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0731-7085&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000385991600009
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923112445
Appears in Collections:	[Wang-Chou Sung] Periodical Articles

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