國家衛生研究院 NHRI:Item 3990099045/8539
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    题名: Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children
    作者: Hong, XM;Hao, K;Ladd-Acosta, C;Hansen, KD;Tsai, HJ;Liu, X;Xu, X;Thornton, TA;Caruso, D;Keet, CA;Sun, Y;Wang, G;Luo, W;Kumar, R;Fuleihan, R;Singh, AM;Kim, JS;Story, RE;Gupta, RS;Gao, P;Chen, Z;Walker, SO;Bartell, TR;Beaty, TH;Fallin, MD;Schleimer, R;Holt, PG;Nadeau, KC;Wood, RA;Pongracic, JA;Weeks, DE;Wang, XB
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the Chicago Food Allergy Study, and identify peanut allergy (PA)-specific loci in the HLA-DR and -DQ gene region at 6p21.32, tagged by rs7192 (P=5.5 x 10(-8)) and rs9275596 (P=6.8 x 10(-10)), in 2,197 participants of European ancestry. We replicate these associations in an independent sample of European ancestry. These associations are further supported by meta-analyses across the discovery and replication samples. Both single-nucleotide polymorphisms (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P<5 x 10(-8)), and differential DNA methylation of the HLA-DQB1 and HLA-DRB1 genes partially mediate the identified SNP-PA associations. This study suggests that the HLA-DR and -DQ gene region probably poses significant genetic risk for PA.
    日期: 2015-02-24
    關聯: Nature Communications. 2015 Feb 24;6:Article number 6304.
    Link to: http://dx.doi.org/10.1038/ncomms7304
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000350290300002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923658758
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