國家衛生研究院 NHRI:Item 3990099045/8531
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8531


    Title: The ability of bilirubin in identifying smokers with higher risk of lung cancer: A large cohort study in conjunction with global metabolomic profiling
    Authors: Wen, CP;Zhang, F;Liang, D;Wen, C;Gu, J;Skinner, H;Chow, WH;Ye, Y;Pu, X;Hildebrandt, MAT;Huang, M;Chen, CH;Hsiung, CA;Tsai, MK;Tsao, CK;Lippman, SM;Wu, X
    Contributors: Division of Health Services and Preventive Medicine;Division of Biostatistics and Bioinformatics
    Abstract: Purpose: We aimed to identify serum metabolites as potential valuable biomarkers for lung cancer and to improve risk stratification in smokers. Experimental Design: We performed global metabolomic profiling followed by targeted validation of individual metabolites in a case-control design of 386 lung cancer cases and 193 matched controls. Wethen validated bilirubin, which consistently showed significant differential levels in cases and controls, as a risk marker for lung cancer incidence and mortality in a large prospective cohort composed of 425,660 participants. Results: Through global metabolomic profiling and following targeted validation, bilirubin levels consistently showed a statistically significant difference among healthy controls and lung cancer cases. In the prospective cohort, the inverse association was only seen in male smokers, regardless of smoking pack-years and intensity. Compared with male smokers in the highest bilirubin group (>1 mg/dL), those in the lowest bilirubin group (<0.75 mg/dL) had 55% and 66% increase in risks of lung cancer incidence and mortality, respectively. For every 0.1 mg/dL decrease of bilirubin, the risks for lung cancer incidence and mortality increased by 5% and 6% in male smokers, respectively (both P < 0.001). There was a significant interaction between low serum bilirubin level and smoking on lung cancer risk (Pinteraction = 0.001). Conclusion: Low levels of serum bilirubin are associated with higher risks of lung cancer incidence and mortality in male smokers and can be used to identify higher risk smokers for lung cancer.
    Date: 2015-01-01
    Relation: Clinical Cancer Research. 2015 Jan 1;21(1):193-200.
    Link to: http://dx.doi.org/10.1158/1078-0432.CCR-14-0748
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1078-0432&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000347462600024
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920687427
    Appears in Collections:[Chi-Pang Wen(2001-2010)] Periodical Articles
    [Chao A. Hsiung] Periodical Articles

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