國家衛生研究院 NHRI:Item 3990099045/8516

NHRI > National Institute of Infectious Diseases and Vaccinology > Horng-Yunn Dou > Periodical Articles > Item 3990099045/8516

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8516

Title:	Molecular epidemiology of tuberculosis in Kaohsiung city located at southern Taiwan, 2000-2008
Authors:	Chen, YY;Chang, JR;Kuo, SC;Tseng, FC;Huang, WC;Huang, TS;Chen, YS;Chiueh, TS;Sun, JR;Su, IJ;Dou, HY
Contributors:	Division of Infectious Diseases
Abstract:	Background: We present the first comprehensive analysis of Mycobacterium tuberculosis (MTB) isolates circulating in southern Taiwan. In this 9-year population-based study, the TB situation in the Kaohsiung region was characterized by genotypic analysis of 421 MTB isolates. Methods: All 421 isolates of MTB were analyzed by spoligotyping and MIRU-VNTR typing. Drug-resistance patterns were also analyzed. Results: The percentage of EAI (East African-Indian) strains increased across sampling years (2000–2008) in southern Taiwan, whereas the proportion of Beijing lineages remained unchanged. Clustering was more frequent with EAI genotype infections (odds ratio = 3.6, p<0.0001) when compared to Beijing genotypes. Notably, MTB resistance to streptomycin (STR) had significantly increased over time, but resistance to other antibiotics, including multidrug resistance, had not. Three major genes (gidB, rpsL and rrs) implicated in STR resistance were sequenced and specific mutations identified. Conclusions: This study revealed that EAI strains were highly transmissible and that STR resistance has increased between 2000 and 2008 in Kaohsiung, Taiwan.
Date:	2015-01-28
Relation:	PLoS ONE. 2015 Jan 28;10(1):Article number e0117061.
Link to:	http://dx.doi.org/10.1371/journal.pone.0117061
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000348732100061
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84961288610
Appears in Collections:	[Horng-Yunn Dou] Periodical Articles [Ih-Jen Su(2002-2015)] Periodical Articles [Fan-Chen Tseng] Periodical Articles [Shu-Chen Kuo] Periodical Articles

Files in This Item:

File	Description	Size	Format
PLO2015020201.pdf		539Kb	Adobe PDF	651	View/Open

Loading...