國家衛生研究院 NHRI:Item 3990099045/8506
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856615      線上人數 : 756
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8506


    題名: Roles of high oscillatory shear stress-induced histone deacetylases expression in arteriovenous fistula failure
    作者: Yang, T;Lin, C;Lin, W;Lee, P;Chiu, J
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: The high incidence and prevalence of end-stage renal disease (ESRD) in Taiwan has been an important public health problem. In Taiwan, 90.96% of these patients are managed on maintenance hemodialysis. An autogenous arteriovenous fistula (AVF) has been commonly used as the vascular access in hemodialysis but there are significant problems associated with AVF failure. The main complications of AVF include thrombosis, stenosis, and vascular access infections. AVF operation causes hemodynamic environmental changes such as shear stress. The shear stress has been identified as playing important roles in regulating the vascular endothelial dysfunction. Histone deacetylases (HDACs) are important epigenetic factors that regulate cellular functions involving inflammatory and proliferative. Recent studies show that their expressions in endothelial cells are regulated by shear stress. Thus, we hypothesize that HDACs may play critical roles in venous endothelial cells (ECs) dysfunction and AVF failure. In this project, we have identified flow patterns and the expressions of HDACs in different locations of the AVF vessels (anastomosis and distal vein) by Doppler ultrasound and immunostaining. In addition, we generated rat AVF model to simulate human AVF condition and checked the relationship between the activation of HDACs and flow patterns. In Doppler ultrasound results, we found that high velocities and oscillatory shear stress (HOSS) existed in the anastomosis of the human and rat AVF vessels, whereas corresponding low velocities and laminar flow existed in the normal vein. In immunostaining results, HDAC-1/2/3 were activated in the anastomosis and proximal vein ECs in the venous limb of the human and rat AVF model. These results indicated that high and oscillatory shear stress can cause HDAC activation in venous ECs which may play some important roles in the development of AVF failure.
    日期: 2014-04
    關聯: FASEB Journal. 2014 Apr;28(1 Suppl.):Article number LB218.
    Link to: http://www.fasebj.org/content/28/1_Supplement/LB218.abstract?sid=8bc9bd5f-0407-4ec0-bebc-2ac8742392dd
    Cited Times(WOS): http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=RID&SrcApp=RID&DestLinkType=FullRecord&DestApp=ALL_WOS&KeyUT=000346651004303
    顯示於類別:[楊良棟] 會議論文/會議摘要
    [裘正健] 會議論文/會議摘要

    文件中的檔案:

    沒有與此文件相關的檔案.



    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋