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http://ir.nhri.org.tw/handle/3990099045/8482
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| Title: | Turmeric improves post-prandial working memory in pre-diabetes independent of insulin |
| Other Titles: | 薑黃改善糖尿病前期患者餐後工作記憶之代謝研究 |
| Authors: | Lee, MS;Wahlqvist, ML;Chou, YC;Fang, WH;Lee, JT;Kuan, JC;Liu, HY;Lu, TM;Xiu, L;Hsu, CC;Andrews, ZB;Pan, WH |
| Contributors: | Division of Health Services and Preventive Medicine |
| Abstract: | BACKGROUND AND OBJECTIVES: Cognitive impairment develops with pre-diabetes and dementia is a complication of diabetes. Natural products like turmeric and cinnamon may ameliorate the underlying pathogenesis. METHODS: People >=60 years (n=48) with newly-recognised untreated pre-diabetes were randomised to a double-blind metabolic study of placebo, turmeric (1 g), cinnamon (2 g) or both (1 g & 2 g respectively), ingested at a white bread (119 g) breakfast. Observations were made over 6 hours for pre- and post-working memory (WM), glycaemic and insulin responses and biomarkers of Alzheimer's disease (AD)(0, 2, 4 and 6 hours): amyloid precursor protein (APP), gamma-secretase subunits presenilin-1 (PS1), presenilin-2 (PS2), and glycogen synthase kinase (GSK-3beta). Differences between natural product users and non-users were determined by Students t and chi square tests; and between pre-test and post-test WM by Wilcoxon signed rank tests. Interaction between turmeric and cinnamon was tested by 2-way ANOVA. Multivariable linear regression (MLR) took account of BMI, glycaemia, insulin and AD biomarkers in the WM responses to turmeric and cinnamon. RESULTS: No interaction between turmeric and cinnamon was detected. WM increased from 2.6 to 2.9 out of 3.0 (p=0.05) with turmeric, but was unchanged with cinnamon. WM improvement was inversely associated with insulin resistance (r=-0.418, p<0.01), but not with AD biomarkers. With MLR, the WM responses to turmeric were best predicted with an R2 of 34.5%; and with significant turmeric, BMI and insulin/glucose AUC beta-coefficients. CONCLUSIONS: Co-ingestion of turmeric with white bread increases working memory independent of body fatness, glycaemia, insulin, or AD biomarkers. Publisher: Abstract available from the publisher. chi |
| Date: | 2014-12 |
| Relation: | Asia Pacific Journal of Clinical Nutrition. 2014 Dec;23(4):581-591. |
| Link to: | http://dx.doi.org/10.6133/apjcn.2014.23.4.24 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-7058&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000347143600010 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925546659 |
| Appears in Collections: | [潘文涵] 期刊論文
[許志成] 期刊論文
[MARK LAWRENCE WAHLQVIST(2008-2012)] 期刊論文
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| PUB25516316.pdf | | 619Kb | Adobe PDF | 491 | View/Open |
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