國家衛生研究院 NHRI:Item 3990099045/8464
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    题名: Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots
    作者: Liu, BR;Chen, HH;Chan, MH;Huang, YW;Aronstam, RS;Lee, HJ
    贡献者: Center for Neuropsychiatric Research
    摘要: Nanoparticles, such as semiconductor quantum dots (QDs), have been found increasing use in biomedical diagnosis and therapeutics because of their unique properties, including quantum confinement, surface plasmon resonance, and superparamagnetism. Cell-penetrating peptides (CPPs) represent an efficient mechanism to overcome plasma membrane barriers and deliver biologically active molecules into cells. In this study, we demonstrate that three arginine-rich CPPs (SR9, HR9, and PR9) can noncovalently complex with red light emitting QDs, dramatically increasing their delivery into living cells. Zeta-potential and size analyses highlight the importance of electrostatic interactions between positive-charged CPP/QD complexes and negative-charged plasma membranes indicating the efficiency of transmembrane complex transport. Subcellular colocalization indicates associations of QD with early endosomes and lysosomes following PR9-mediated delivery. Our study demonstrates that nontoxic CPPs of varied composition provide an effective vehicle for the design of optimized drug delivery systems.
    日期: 2015-03
    關聯: Journal of Nanoscience and Nanotechnology. 2015 Mar;15(3):2067-2078.
    Link to: http://dx.doi.org/10.1166/jnn.2015.9148
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000345054200019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920818895
    显示于类别:[陳慧諴] 期刊論文

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