國家衛生研究院 NHRI:Item 3990099045/8444

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Title:	Chemical constituents and cytotoxic activities from the root and the stem of Reevesia formosana
Authors:	Chang, HS;Peng, HT;Lee, SJ;Lin, CH;Chen, IS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	In our previous studies, we have reported 13 new cardenolide glycosides with potent cytotoxicities, reevesiosides A-I and epi-reevesiosides F-I from the root of Reevesia formosana (Sterculiaceae). Continuing investigation of the root and the stem of this species led to the isolation of three new lignanoids, reevesic acid, reevesilignan, and reevesiacoumarin, two new sesquiterpenes, reevesiterpenol A and reevesiterpenol B, one new triterpene, 3α,27-di-O-caffeoylbetulinic acid, along with 37 known compounds including nine lignanoids, eight triterpenes, six steroids, four sesquiterpenes, three coumarins, three cardenolide glycosides, two benzenoids, one proanthocyanidin, and Q10. Three additional known cardenolide glycosides, strophathojavoside, strophalloside, and ascleposide isolated from the root of this plant also displayed potent cytotoxicity against the MCF-7, NCI-H460, and Hep G2 cancer cell lines, with IC50 values of 0.767 ± 0.031, 0.175 ± 0.011, and 0.649 ± 0.06; 3.456± 0.130, 0.62 ± 0.059, and 2.593 ± 0.132; 0.166 ± 0.015, 0.037 ± 0.002, and 0.374 ± 0.020µM, respectively. The new triterpene, 3α,27-di-O-caffeoylbetulinic acid isolated from the stem of this species showed a moderate cytotoxicity against NCI-H460 cancer cell line. The structures of these compounds were elucidated by spectroscopic techniques.
Date:	2014-11
Relation:	Planta Medica. 2014 Nov;80(16):1541.
Link to:	https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395065
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000345550400591
Appears in Collections:	[Shiow-Ju Lee] Conference Papers/Meeting Abstract

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