國家衛生研究院 NHRI:Item 3990099045/8400

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Title:	Distinct modes of transmission of tuberculosis in aboriginal and non-aboriginal populations in Taiwan
Authors:	Chen, YY;Tseng, FC;Chang, JR;Kuo, SC;Lee, JJ;Yeh, JJ;Chiueh, TS;Sun, JR;Su, IJ;Dou, HY
Contributors:	Division of Infectious Diseases
Abstract:	Tuberculosis incidence among aborigines is significantly higher than for Han Chinese in Taiwan, but the extent to which Mycobacterium tuberculosis (MTB) strain characteristics contribute to this difference is not well understood. MTB isolates from aborigines and Han Chinese living in eastern and southern Taiwan, the major regions of aborigines, were analyzed by spoligotyping and 24-loci MIRU-VNTR. In eastern Taiwan, 60% of aboriginal patients were ≤20 years old, significantly younger than the non-aboriginal patients there; aborigines were more likely to have clustered MTB isolates than Han Chinese (odds ratio (OR) = 5.98, p<0.0001). MTB lineages with high clustering were EAI (54.9%) among southern people, and Beijing (62.5%) and Haarlem (52.9%) among eastern aborigines. Resistance to first-line drugs and multidrug resistance (MDR) were significantly higher among eastern aborigines (≥15%) than in any other geographic and ethnic group (p<0.05); MDR was detected in 5 of 28 eastern aboriginal patients ≤20 years old. Among patients from the eastern region, clustered strains (p = 0.01) and aboriginal ethnicity (p = 0.04) were independent risk factors for MDR. The lifestyles of aborigines in eastern Taiwan may explain why the percentage of infected aborigines is much higher than for their Han Chinese counterparts. The significantly higher percentage of the MDR-MTB strains in the aboriginal population warrants close attention to control policy and vaccination strategy.
Date:	2014-11-13
Relation:	PLoS ONE. 2014 Nov 13;9(11):Article number e0112633.
Link to:	http://dx.doi.org/10.1371/journal.pone.0112633
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000347709300078
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84911876237
Appears in Collections:	[Horng-Yunn Dou] Periodical Articles [Ih-Jen Su(2002-2015)] Periodical Articles [Shu-Chen Kuo] Periodical Articles [Fan-Chen Tseng] Periodical Articles

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