國家衛生研究院 NHRI:Item 3990099045/8398

NHRI > National Institute of Infectious Diseases and Vaccinology > Chi-Jung Wu > Periodical Articles > Item 3990099045/8398

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8398

Title:	Virulence diversity among bacteremic aeromonas isolates: Ex vivo, animal, and clinical evidences
Authors:	Chen, PL;Wu, CJ;Tsai, PJ;Tang, HJ;Chuang, YC;Lee, NY;Lee, CC;Li, CW;Li, MC;Chen, CC;Tsai, HW;Ou, CC;Chen, CS;Ko, WC
Contributors:	Division of Infectious Diseases
Abstract:	BACKGROUND: The objective of this study was to compare virulence among different Aeromonas species causing bloodstream infections. METHODOLOGY/PRINCIPAL FINDINGS: Nine of four species of Aeromonas blood isolates, including A. dhakensis, A. hydrophila, A. veronii and A. caviae were randomly selected for analysis. The species was identified by the DNA sequence matching of rpoD. Clinically, the patients with A. dhakensis bacteremia had a higher sepsis-related mortality rate than those with other species (37.5% vs. 0%, P = 0.028). Virulence of different Aeromonas species were tested in C. elegans, mouse fibroblast C2C12 cell line and BALB/c mice models. C. elegans fed with A. dhakensis and A. caviae had the lowest and highest survival rates compared with other species, respectively (all P values <0.0001). A. dhakensis isolates also exhibited more cytotoxicity in C2C12 cell line (all P values <0.0001). Fourteen-day survival rate of mice intramuscularly inoculated with A. dhakensis was lower than that of other species (all P values <0.0001). Hemolytic activity and several virulence factor genes were rarely detected in the A. caviae isolates. CONCLUSIONS/SIGNIFICANCE: Clinical data, ex vivo experiments, and animal studies suggest there is virulence variation among clinically important Aeromonas species.
Date:	2014-11-06
Relation:	PLoS ONE. 2014 Nov 6;9(11):Article number e111213.
Link to:	http://dx.doi.org/10.1371/journal.pone.0111213
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000344402600031
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84909989293
Appears in Collections:	[Chi-Jung Wu] Periodical Articles

Files in This Item:

File	Description	Size	Format
PUB25375798.pdf		450Kb	Adobe PDF	559	View/Open

Loading...