國家衛生研究院 NHRI:Item 3990099045/8385
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8385


    Title: Interactions of nitroxide radicals with dendrimer-entrapped Au8-clusters: A fluorescent nanosensor for intracellular imaging of ascorbic acid
    Authors: Liu, CP;Wu, TH;Liu, CY;Cheng, HJ;Lin, SY
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: When gold nanoparticles (AuNPs) become extremely small (<2 nm in diameter) as gold nanoclusters (AuNCs), an intriguing issue is whether the interactions of free radicals with AuNCs would be essentially different at sufficiently small size. Herein, we report for the first time that the fluorescence of a polyamidoamine (PAMAM) dendrimer-entrapped Au8-cluster is quenched by the paramagnetic nitroxide radical. Based on an upward curving Stern-Volmer plot, the system shows complex fluorescence quenching with a combination of static and dynamic quenching processes. The quenching mechanism associated with the interactions between Au8-clusters and nitroxide radicals was explored by combined fluorescence and electron paramagnetic resonance (EPR) studies. The controlled quenching of the fluorescent Au8-cluster can be developed as a turn-on fluorescence probe for sensing ascorbic acid (AA) in living cells.
    Date: 2015-01
    Relation: Journal of Materials Chemistry B. 2015 Jan;3:191-197.
    Link to: http://dx.doi.org/10.1039/c4tb01657b
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000346061000005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84916885568
    Appears in Collections:[Shu-Yi Lin] Periodical Articles

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