國家衛生研究院 NHRI:Item 3990099045/8320
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8320


    Title: Hepatitis C virus infection increases the risk of developing peripheral arterial disease: A 9-year population-based cohort study
    Authors: Hsu, YH;Muo, CH;Liu, CY;Tsai, WC;Hsu, CC;Sung, FC;Kao, CH
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: BACKGROUND & AIMS: The relationship between hepatitis C virus (HCV) infection and peripheral arterial disease (PAD) development remains unclear. METHODS: Health insurance claims data were used to construct a cohort of HCV-infected patients who were diagnosed in 1998-2011. Patients younger than 20 years and those with history of hepatitis B or PAD were excluded. We selected 7641 HCV-infected patients and 30564 matched controls. The adjusted risk of developing PAD was analyzed using a multivariate Cox hazard model. RESULTS: The results show that the excess risk of PAD development in HCV-infected patients is 1.43-fold higher (95% CI = 1.23-1.67) compared with non-HCV patients. The adjusted risk of PAD development increased with age; compared with the 20-34 year-old patients, the risk is 3.96-fold higher in HCV-infected patients aged 35-49 years, and 11.7-fold higher in those aged 65 years and above. CKD/ESRD has highest risk for PAD (HR = 1.80, 95% CI = 1.29-2.53). HCV-infected patients with four comorbidities exhibited a substantially higher risk of developing PAD (HR=9.25, 95% CI = 6.35-13.5). Excess risk of developing PAD was observed since within the first year of follow-up till the third year. CONCLUSION: HCV-infected patients have an independently higher risk of developing PAD. HCV-infected patients with comorbidity have increased risk of developing PAD.
    Date: 2015-03
    Relation: Journal of Hepatology. 2015 Mar;62(3):519-525.
    Link to: http://dx.doi.org/10.1016/j.jhep.2014.09.022
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-8278&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000349855400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922989531
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles

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