國家衛生研究院 NHRI:Item 3990099045/8303

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Title:	Long-term clinical outcome of major adverse cardiac events in survivors of infective endocarditis: A nationwide population-based study
Authors:	Shih, CJ;Chu, H;Chao, PW;Lee, YJ;Kuo, SC;Li, SY;Tarng, DC;Yang, CY;Yang, WC;Ou, SM;Chen, YT
Contributors:	Division of Infectious Diseases
Abstract:	BACKGROUND: -Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard endpoints (i.e., stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors. METHODS AND RESULTS: -A nationwide population-based cohort study was conducted among IE survivors identified using Taiwan's National Health Insurance Research Database during 2000-2009. IE survivors were defined as those who survived after discharge from first hospitalization with a diagnosis of IE. A total of 10,116 IE survivors were identified. IE survivors were matched to control subjects without IE at a 1:1 ratio using propensity scores. The primary outcomes were stroke, myocardial infarction, readmission for heart failure, and sudden cardiac death or ventricular arrhythmia. The secondary outcomes were repeat IE and all-cause mortality. Compared with the matched cohort, IE survivors had higher risks of ischemic stroke (adjusted hazard ratio [aHR], 1.59; 95% confidence interval [CI], 1.40 to 1.80), hemorrhagic stroke (aHR, 2.37; 95% CI, 1.90 to 2.96), myocardial infarction (aHR, 1.44; 95% CI, 1.17 to 1.79), readmission for heart failure (aHR, 2.24; 95% CI, 2.05 to 2.43), sudden death or ventricular arrhythmia (aHR, 1.69; 95% CI, 1.44 to 1.98) and all-cause death (aHR, 2.27; 95% CI, 2.14 to 2.40). Risk factors for repeat IE were older age, male sex, drug abuser, and valvular replacement after an initial episode of IE. CONCLUSIONS: -Despite treatment, the risk of long-term major adverse cardiac events was substantially increased in IE survivors.
Date:	2014-11
Relation:	Circulation. 2014 Nov;130(19):1684-1691.
Link to:	http://dx.doi.org/10.1161/circulationaha.114.012717
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-7322&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000344067000011
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84913593394
Appears in Collections:	[Shu-Chen Kuo] Periodical Articles

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