國家衛生研究院 NHRI:Item 3990099045/8276
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 908019      在线人数 : 882
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8276


    题名: Nicastrin is required for zebrafish pigment and brain development
    作者: Chong, SW;Jiang, YJ;Tang, CH;You, MS
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Background: Alzheimer's disease (AD) is the most common form of dementia and neuropathologically characterized by the presence of neurofibrillary tangles and the deposition of β-amyloid (Aβ) in neuritic plagues. So far three genes have been identified that, when mutated, cause early onset AD: Amyloid precursor protein (APP), Presenilin-1 (PS1), and Presenilin-2 (PS2). Nicastrin is a transmembrane glycoprotein whose mutation causes a type of familial Alzheimer's disease (FAD). This protein forms gamma-secretase complex with PS1, PS2, APH-1, PEN-2 and catenins, which is involved in proteolytically processing APP to the short AD-associated peptide β-amyloid. Another well-known substrate of gamma-secretase is Notch. It has been shown that mouse Nicastrin deficiency causes neurodegeneration recently.
    日期: 2014-07
    關聯: Alzheimer's and Dementia. 2014 Jul;10(4, Suppl.):P786.
    Link to: http://dx.doi.org/10.1016/j.jalz.2014.05.1521
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1552-5260&DestApp=IC2JCR
    显示于类别:[江運金] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    SDO1552526014021840.pdf51KbAdobe PDF622检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈