國家衛生研究院 NHRI:Item 3990099045/8233
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 907475      Online Users : 953
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8233


    Title: A novel mechanism for acupuncture-induced analgesia: involvement of orexins and endocannabinoids
    Authors: Chiou, LC;Chen, YH;Lee, HJ;Wu, YT;Lee, YH;Hwang, LL;Hung, MS;Zimmer, A;Mackie, K
    Contributors: Institute of Biotechnology and Pharmaceutical Research
    Abstract: Here, we reveal a novel analgesic mechanism for electroacupuncture. Low frequency electroacupuncture at the PC6 (Neiguan) acupoint (EA-PC6), but not electro-stimulation at a non-acupoint location (NAP) or needle insertion alone, increased the number of c- Fos expressing-orexin neurons in the lateral hypothalamus and orexin A levels in the ventrolateral periaqueductal gray (vlPAG), and induced antinociception in mice. EA-PC6-induced antinociception was signi ? cantly attenuated by systemic or intra-vlPAG pretreatment with the OX1 or CB1 receptor antagonist, and by intra-vlPAG inhibition of the synthesizing enzyme of 2-arachidonoylglycerol (2-AG), but not by systemic pretreatment with opioid receptor antagonists. EA-PC6 elicited a weak antinociceptive effect in Cnr1 / mice. EA-PC6-induced antinociception is not a phenomenon of stress-induced analgesia since EA-PC6 decreased the plasma corticosterone level. These ? ndings suggest that EA-PC6 activates hypothalamic orexin neurons, releasing orexins to induce analgesia through an opioid-independent but CB1 receptor-dependent cascade mediated by an OX1 receptor-initiated 2-AG retrograde disinhibition mechanism 1 in the vlPAG.
    Date: 2014-08
    Relation: Journal of Neurochemistry. 2014 Aug;130(Suppl. s1):38.
    Link to: http://dx.doi.org/10.1111/jnc.12777
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000339492800080
    Appears in Collections:[Ming-Shiu Hung] Conference Papers/Meeting Abstract

    Files in This Item:

    File Description SizeFormat
    ISI000339492800080.pdf148KbAdobe PDF633View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback