國家衛生研究院 NHRI:Item 3990099045/8201
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 916052      線上人數 : 1386
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8201


    題名: MMP11 overexpression: Poor prognosis in patients with urothelial carcinoma of the upper tract and urinary bladder
    作者: Li, WM;Wu, WJ;Huang, CN;Li, CC;Ke, HL;Yeh, HC;Li, CF;Lee, YY;Lin, HH;Yeh, BW;Hwang, SJ;Liang, PI
    貢獻者: National Institute of Cancer Research
    摘要: Background: Through data mining from a published transcriptomic database of urinary bladder urothelial carcinomas (GSE32894), MMP11 was identified as the most significant gene showing stepwise upregulation among those associated with the regulation of metalloendopeptidase activity. We therefore analysed MMP11 protein expression and its association with clinicopathological factors and survival in our well-characterised cohort of urothelial cancers. Methods: Immunohistochemistry evaluated by using H-score was used to determine MMP11 protein expression in 295 urothelial carcinomas of the urinary bladder and 340 urothelial carcinomas of the upper urinary tract, respectively. The medical records of these patients were reviewed retrospectively. The MMP11 expression status was further correlated with clinicopathological features as well as disease-specific survival (DSS) and metastasis-free survival (MeFS). Univariate and multivariate statistical analyses were performed to evaluate the prognostic predictors. Findings: MMP11 protein overexpression was significantly associated with advanced pT status (upper urinary tract, p < 0.001; urinary bladder, p < 0.001), nodal metastasis (upper urinary tract, p < 0.001; urinary bladder, p = 0.012), vascular invasion (upper urinary tract, p < 0.001; urinary bladder, p < 0.001), and perineural invasion (upper urinary tract, p = 0.002; urinary bladder, p = 0.006) in both groups of urothelial carcinomas. MMP11 overexpression not only predicted worse DSS (upper urinary tract, p < 0.0001; urinary bladder, p < 0.0001) and MeFS (upper urinary tract, p < 0.0001; urinary bladder, p < 0.0001) at univariate analysis, but also inferior DSS (upper urinary tract, p = 0.005; urinary bladder, p = 0.010) and MeFS (upper urinary tract, p = 0.018; urinary bladder, p = 0.026) in multivariate analysis. Interpretation: MMP11 overexpression is associated with more aggressive tumour phenotype and poor prognosis for patients with urothelial carcinomas of the upper urinary tract and urinary bladder, suggesting it may serve as a potential prognostic and a novel therapeutic target of urothelial carcinoma.
    日期: 2014-05
    關聯: European Journal of Cancer. 2014 May;50(Suppl. 4):e43.
    Link to: http://dx.doi.org/10.1016/j.ejca.2014.03.164
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000351589200120
    顯示於類別:[其他] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SDO0959804914004365.pdf35KbAdobe PDF476檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋