國家衛生研究院 NHRI:Item 3990099045/8199
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    题名: Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish
    作者: Chen, CH;Lin, DS;Cheng, CW;Lin, CJ;Lo, YK;Yen, CC;Lee, AY;Hsiao, CD
    贡献者: National Institute of Cancer Research
    摘要: Aberration in DNA replication is a major cause to genome instability that is a hallmark of cancer cells. Cell division cycle 6 (Cdc6) and c-Myc have a critical role in the initiation of DNA replication. However, whether their interaction induces epithelial-mesenchymal transition (EMT) and promotes tumorigenesis in in vivo animal model remains unclear. Since using zebrafish as a cancer model has been restricted by the late onset of tumorigenesis and extreme difficulty in transformation on skin, we tried to establish a novel non-melanoma skin model in zebrafish to study their role in tumorigenesis. A stable transgenic zebrafish was created by using tol2 transposon, in which cdc6 and c-myc were co-overexpressed in epidermis driven by a skin-specific krt4 promoter. Intriguingly, co-overexpression of cdc6 and c-myc in transgenic zebrafish skin triggered tumor-like transformation, apoptosis attenuation, genomic instability, and EMT, hallmarks of malignant tumorigenesis. Our findings and other characteristics of zebrafish, including optical clarity and small molecule treatment, provide the future utility of this model for easy and non-invasive detection and for identification of new anti-cancer drug.
    日期: 2014-08
    關聯: Oncotarget. 2014 Aug;5(15):6300-6311.
    Link to: http://dx.doi.org/10.18632/oncotarget.2204
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000347919500036
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906272495
    显示于类别:[李岳倫] 期刊論文

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