國家衛生研究院 NHRI:Item 3990099045/8171
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8171


    Title: Insulin Resistance: Regression and clustering
    Authors: Yoon, S;Assimes, TL;Quertermous, T;Hsiao, CF;Chuang, LM;Hwu, CM;Rajaratnam, B;Olshen, RA
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: In this paper we try to define insulin resistance (IR) precisely for a group of Chinese women. Our definition deliberately does not depend upon body mass index (BMI) or age, although in other studies, with particular random effects models quite different from models used here, BMI accounts for a large part of the variability in IR. We accomplish our goal through application of Gauss mixture vector quantization (GMVQ), a technique for clustering that was developed for application to lossy data compression. Defining data come from measurements that play major roles in medical practice. A precise statement of what the data are is in Section 1. Their family structures are described in detail. They concern levels of lipids and the results of an oral glucose tolerance test (OGTT). We apply GMVQ to residuals obtained from regressions of outcomes of an OGTT and lipids on functions of age and BMI that are inferred from the data. A bootstrap procedure developed for our family data supplemented by insights from other approaches leads us to believe that two clusters are appropriate for defining IR precisely. One cluster consists of women who are IR, and the other of women who seem not to be. Genes and other features are used to predict cluster membership. We argue that prediction with "main effects'' is not satisfactory, but prediction that includes interactions may be.
    Date: 2014-06-02
    Relation: PLoS ONE. 2014 Jun 2;9(6):Article number e94129.
    Link to: http://dx.doi.org/10.1371/journal.pone.0094129
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000336956300004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902326999
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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