國家衛生研究院 NHRI:Item 3990099045/8167
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8167


    Title: Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan
    Authors: Chang, JS;Lin, SM;Chao, JCJ;Chen, YC;Wang, CM;Chou, NH;Pan, WH;Bai, CH
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Objectives Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. Design A population-based, cross-sectional study. Setting National Nutrition and Health Survey in Taiwan and Penghu Island. Subjects A total of 2638 healthy adults aged ?19 years. Three ethnic groups were included. Results Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. Conclusions Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.
    Date: 2014-07
    Relation: Public Health Nutrition. 2014 Jul;17(7):1498-1506.
    Link to: http://dx.doi.org/10.1017/S1368980013001596
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1368-9800&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000339620900009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901854118
    Appears in Collections:[Wen-Harn Pan] Periodical Articles

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