國家衛生研究院 NHRI:Item 3990099045/8123
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 908438      在线人数 : 993
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8123


    题名: Interpretable prediction of non-genotoxic hepatocarcinogenic chemicals
    作者: Tung, CW;Jheng, JL
    贡献者: National Environmental Health Research Center
    摘要: The assessment of non-genotoxic hepatocarcinogenicity of chemicals relies on time-consuming rodent bioassays. The development of alternative methods for non-genotoxic hepatocarcinogenicity could help the identification of potential hepatocarcinogenic chemicals. This study evaluated four types of features for the interpretable prediction of non-genotoxic hepatocarcinogenic chemicals including chemical-chemical interactions (CCI), chemical-protein interactions (CPI), chemical descriptors (QSAR) and gene expression profiles (TGx). Based on the results of decision tree classifiers, the CPI-based features perform best with independent test accuracies of 90% and 86% for interaction scores from combined scores and databases, respectively. Informative features were identified and analyzed to give insights into the non-genotoxic hepatocarcinogenicity of chemicals. The difference between CPI scores and gene expression profiles for the identified important proteins shows that CPI could play more important roles in non-genotoxic hepatocarcinogenicity.
    日期: 2014-12
    關聯: Neurocomputing. 2014 Dec;145:68-74.
    Link to: http://dx.doi.org/10.1016/j.neucom.2014.05.073
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0925-2312&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000342248100010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906935725
    显示于类别:[童俊維] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SDO0925231214008054.pdf1654KbAdobe PDF444检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈