國家衛生研究院 NHRI:Item 3990099045/8103
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    题名: Baicalin, a metabolite of baicalein with antiviral activity against dengue virus
    作者: Moghaddam, E;Teoh, BT;Sam, SS;Lani, R;Hassandarvish, P;Chik, Z;Yueh, A;Abubakar, S;Zandi, K
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Baicalin, a flavonoid derived from Scutellaria baicalensis, is the main metabolite of baicalein released following administration in different animal models and human. We previously reported the antiviral activity of baicalein against dengue virus (DENV). Here, we examined the anti-DENV properties of baicalin in vitro, and described the inhibitory potentials of baicalin at different steps of DENV-2 (NGC strain) replication. Our in vitro antiviral experiments showed that baicalin inhibited virus replication at IC50 = 13.5 +/- 0.08 mug/ml with SI = 21.5 following virus internalization by Vero cells. Baicalin exhibited virucidal activity against DENV-2 extracellular particles at IC50 = 8.74 +/- 0.08 mug/ml and showed anti-adsorption effect with IC50 = 18.07 +/- 0.2 mug/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted.
    日期: 2014-06-26
    關聯: Scientific Reports. 2014 Jun 26;4:Article number 5452.
    Link to: http://dx.doi.org/10.1038/srep05452
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000337892000001
    https://www.webofscience.com/wos/woscc/full-record/WOS:000337892000001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84903291470
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