國家衛生研究院 NHRI:Item 3990099045/8099
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8099


    Title: Suboptimal vitamin d status in a population-based study of asian children: Prevalence and relation to allergic diseases and atopy
    Authors: Yao, TC;Tu, YL;Chang, SW;Tsai, HJ;Gu, PW;Ning, HC;Hua, MC;Liao, SL;Tsai, MH;Chiu, CY;Lai, SH;Yeh, KW;Huang, JL;PATCH Study Group
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: BACKGROUND: New evidence shows high prevalence of vitamin D deficiency in many countries and some studies suggest a possible link between vitamin D status and allergic diseases. The objectives of this study were to determine the prevalence of suboptimal vitamin D status in a population sample of Asian children and to investigate the relationship of vitamin D status with allergic diseases and atopy. METHODS: Children aged 5-18 years (N = 1315) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were evaluated using questionnaires, anthropometric measurements, and serum levels of 25-hydroxyvitamin D [25(OH)D] and total and specific immunoglobulin E (IgE). RESULTS: The mean concentration of serum 25(OH)D was 20.4 ng/mL (SD: 7.1 ng/mL). Vitamin D deficiency (defined as serum 25(OH)D<20 ng/mL) was present in 670 subjects (51.0%), while vitamin D insufficiency (defined as serum 25(OH)D<30 ng/mL) was observed in 1187 subjects (90.3%). Older age (P<0.001), female gender (P<0.001), higher body mass index (P = 0.001), winter and spring seasons (compared to summer; P both<0.001), and passive smoking (P = 0.011) were independently associated with low serum 25(OH)D levels. After adjusting for potential confounders, serum 25(OH)D status had no association with asthma, rhinitis, eczema, atopy, or total serum IgE (all P>0.05). CONCLUSIONS: Low serum 25(OH)D levels are remarkably common in this population sample of Asian children, suggesting that millions of children living in Taiwan may have suboptimal levels of vitamin D, which should be a matter of public health concern. Our results provides epidemiological evidence against the association of vitamin D status with various allergic diseases and atopy in Asian children.
    Date: 2014-06-03
    Relation: PLoS ONE. 2014 Jun 3;9(6):Article number e99105.
    Link to: http://dx.doi.org/10.1371/journal.pone.0099105
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000336911400126
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902440680
    Appears in Collections:[Hui-Ju Tsai] Periodical Articles

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