國家衛生研究院 NHRI:Item 3990099045/8086
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    題名: Wave reflection intensity on admission predicts post-discharge events in patients hospitalized due to acute heart failure
    作者: Sung, SH;Yu, WC;Cheng, HM;Chuang, SY;Chen, CH
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Aims: The role of wave reflections in the pathogenesis of acute heart failure syndrome (AHFS) remains unclear. The present study investigated the long-term prognostic values of carotid augmentation index (cAI), carotid augmented pressure (cAP), amplitude of the reflected pressure wave from a decomposed carotid pressure wave (Pb), and carotid pulse pressure (PP) on admission in patients hospitalized due to AHFS.Methods and Results: A total of 120 patients (72?14 years, 83.3% men) hospitalized due to AHFS (55.8% with systolic heart failure) were enrolled. Measures of cAI, cAP, Pb, carotid PP, and carotid-femoral pulse wave velocity (cf-PWV) by tonometry and thoracic fluid content (TFC) by impedance cardiography were obtained within 24 hours of admission. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were determined before discharge. Patients were followed up for a median of 601 days, accruing 66 adverse events including re-hospitalization for heart failure, non-fatal myocardial infarction, non-fatal stroke, and death. In uni-variate Cox analysis, all measures significantly predicted post-discharge events (all P<0.05). In multi-variate analysis, cAP [hazard ratio per 1-s.d. and 95% confidence interval: 1.32 (1.051-1.67), P = 0.017], Pb [1.44 (1.13-1.84), P = 0.004] and carotid PP [1.35 (1.05-1.73), P = 0.019], but not cAI, TFC or cf-PWV, significantly independently predicted events with adjustments for age, estimated glomerular filtration rate, hemoglobin, and NT-proBNP.Conclusions: On-admission measures of wave reflection intensity, including cAP, Pb, and carotid PP, may be useful for predicting long-term outcomes in AHFS patients. The results support a major role of wave reflection in the pathogenesis of AHFS.
    日期: 2012-11
    關聯: Circulation. 2012 Nov;126(21):Abstract number 12412.
    Link to: http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/A12412
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-7322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000208885002246
    顯示於類別:[莊紹源] 會議論文/會議摘要

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