國家衛生研究院 NHRI:Item 3990099045/8083
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    題名: Metformin may reduce breast cancer risk in Taiwanese women with type 2 diabetes
    作者: Tseng, CH
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Whether metformin therapy affects breast cancer risk in Asian patients with type 2 diabetes mellitus (T2DM) has not been investigated. The reimbursement databases of Taiwanese female patients with a new diagnosis of T2DM between 1998 and 2002 (n = 476,282) were retrieved from the National Health Insurance for follow-up of breast cancer until the end of 2009. Metformin was treated as a time-dependent variable; and of these patients, 285,087 were never-users and 191,195 were ever-users. A time-dependent approach was used to calculate breast cancer incidence and estimate hazard ratios by Cox regression for ever-users, never-users, and subgroups of metformin exposure (tertiles of cumulative duration and cumulative dose). During follow-up, 2,412 (1.26 %) metformin ever-users and 9,322 (2.10 %) never-users developed breast cancer, representing an incidence of 201.08 and 535.88 per 100,000 person-years, respectively. The overall multivariable-adjusted hazard ratio (95 % confidence intervals) for ever- versus never-users was 0.630 (0.597-0.665). The multivariable-adjusted hazard ratios for the first, second, and third tertiles of cumulative duration of metformin therapy were 1.122 (1.043-1.207), 0.754 (0.692-0.820), and 0.280 (0.253-0.310), respectively, (P-trend < 0.0001); and 1.099 (1.021-1.182), 0.664 (0.611-0.723), and 0.311 (0.281-0.344), respectively, (P-trend < 0.0001), for cumulative dose of metformin. Metformin use is associated with a decreased risk of breast cancer.
    日期: 2014-06
    關聯: Breast Cancer Research and Treatment. 2014 Jun;145(3):785-790.
    Link to: http://dx.doi.org/10.1007/s10549-014-2985-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0167-6806&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000336441200021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901623124
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