國家衛生研究院 NHRI:Item 3990099045/8069

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8069

Title:	Using chinese herbal medicine containing mu-tong is associated with upper urinary tract cancer in patient with end-stage renal disease
Authors:	Hwang, SJ;Lin, MY;Lee, HL;Lin, HL;Li, WM;Wu, WJ;Huang, CH;Chen, LT
Contributors:	National Institute of Cancer Research
Abstract:	Introduction and Aims: Chinese herbs containing aristolochic acid had been reported causing renal disease and increasing risk of upper urinary tract cancer (UTUC). However, the complexity of the composites of Chinese herbal drugs raises the difficulty to explore the relationship among herb, kidney disease, and cancer. The study is aimed to identify the possibility of Chinese herbs associated with the risk of UTUC in patients with end-stage renal disease (ESRD), through Taiwan National Health Insurance Research Database. Methods: The study population included patients of ESRD from 1997 to 2008. Patient who suffered from upper urinary tract cancer during the study period was considered as potential case, and a 1:5 matching with ESRD patients without UTUC. Chinese herb drugs, frequently prescribed in dataset of National Health Insurance including 15 brand names for Mu-Tong, and 15 for Xi-Xin, were identified and traced up to 1 to 2 year before cancer diagnosis. Conditional logistic regression was used to access the independent factors associated with UTUC in case and control groups. All statistic tests were considered as significant while p-value less than 0.05. Results: Totally, there were 667 ESRD patients with UTUC and corresponding to their age- and sex- 3,335 matched ESRD control subjects for final analyses. After adjusting area, urbanization of residence, income, and Charlson index, increased risk of UTUC was found on overall Mu-Tong used [Odds ratio (95% CI): 1.75 (1.23-2.50), p=0.002) but not on overall Xi-Xin used [0.98 (0.70-1.36), p=0.88]. Furthermore, we found the Long Dan Xie Gan Tang [1.98 (1.20-3.28), p=0.008] and Ba Zheng San [3.58 (1.71-7.49), p<0.0001] listed in Mu-Tong brand names were associated with increased risk of UTUC. Conclusions: Our finding provides critical evidences for possible connection of aristolochic acid and UTUC in patient with ESRD. The results also target specific Chinese herbs needed for further clarification in the future, particularly in the countries of rapidly increasing population using Chinese herbal medicines over the world.
Date:	2014-05
Relation:	Nephrology, Dialysis, Transplantation. 2014 May;29(Suppl. 3):iii65-iii67.
Link to:	http://dx.doi.org/10.1093/ndt/gfu139
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0931-0509&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000338013500155
Appears in Collections:	[Li-Tzong Chen] Conference Papers/Meeting Abstract

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