國家衛生研究院 NHRI:Item 3990099045/8033
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    题名: The use of ADSCs as a treatment for chronic stroke
    作者: Chan, TM;Harn, HJ;Lin, HP;Chiu, SC;Lin, PC;Wang, HI;Ho, LI;Chuu, CP;Chiou, TW;Hsieh, AC;Chen, YW;Ho, WY;Lin, SZ
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagic-induced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure.
    日期: 2014-04
    關聯: Cell Transplantation. 2014 Apr;23(4-5):541-547.
    Link to: http://dx.doi.org/10.3727/096368914x678409
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0963-6897&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000333884900015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84900412710
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