國家衛生研究院 NHRI:Item 3990099045/8032
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    題名: ADSC therapy in neurodegenerative disorders
    作者: Chan, TM;Chen, JYR;Ho, LI;Lin, HP;Hsueh, KW;Liu, DD;Chen, YH;Hsieh, AC;Tsai, NM;Hueng, DY;Tsai, ST;Chou, PW;Lin, SZ;Harn, HJ
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases. However, these diseases all have the common characteristic that they are due to degenerative irreversibility, and thus no efficient drugs or therapy methods can mitigate symptoms completely. Stem cell therapy, such as adipose tissue-derived stem cells (ADSCs), is a promising treatment for incurable disorders. In this review, we summarized the previous studies using ADSCs to treat neurodegenerative disorders, as well as their therapeutic mechanisms. We also suggested possible expectations for future human clinical trials involving minimized intracerebroventricular combined with intravenous administration, using different cell lineages to finish complementary therapy as well as change the extracellular matrix to create a homing niche. Depending on successful experiments in relevant neurodegenerative disorders models, this could form the theoretical basis for future human clinical trials.
    日期: 2014-04
    關聯: Cell Transplantation. 2014 Apr;23(4-5):549-557.
    Link to: http://dx.doi.org/10.3727/096368914x678445
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0963-6897&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000333884900016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84900461138
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