國家衛生研究院 NHRI:Item 3990099045/8014
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8014


    Title: Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥45 years in Asia: A pooled analysis of 21 cohorts
    Authors: Zheng, W;McLerran, DF;Rolland, BA;Fu, Z;Boffetta, P;He, J;Gupta, PC;Ramadas, K;Tsugane, S;Irie, F;Tamakoshi, A;Gao, Y-T;Koh, WP;Shu, XO;Ozasa, K;Nishino, Y;Tsuji, I;Tanaka, H;Chen, CJ;Yuan, JM;Ahn, YO;Yoo, KY;Ahsan, H;Pan, WH;Qiao, YL;Gu, D;Pednekar, MS;Sauvaget, C;Sawada, N;Sairenchi, T;Yang, G;Wang, R;Xiang, YB;Ohishi, W;Kakizaki, M;Watanabe, T;Oze, I;You, SL;Sugawara, Y;Butler, LM;Kim, DH;Park, SK;Parvez, F;Chuang, SY;Fan, JH;Shen, CY;Chen, Y;Grant, EJ;Lee, JE;Sinha, R;Matsuo, K;Thornquist, M;Inoue, M;Feng, Z;Kang, D;Potter, JD
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: BACKGROUND:Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest. METHODS AND FINDINGS:We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then estimated smoking-related deaths among adults aged ≥45 y in 2004 in Bangladesh, India, mainland China, Japan, Republic of Korea, Singapore, and Taiwan-accounting for ∼71% of Asia's total population. An approximately 1.44-fold (95% CI = 1.37-1.51) and 1.48-fold (1.38-1.58) elevated risk of death from any cause was found in male and female ever-smokers, respectively. In 2004, active tobacco smoking accounted for approximately 15.8% (95% CI = 14.3%-17.2%) and 3.3% (2.6%-4.0%) of deaths, respectively, in men and women aged ≥45 y in the seven countries/regions combined, with a total number of estimated deaths of ∼1,575,500 (95% CI = 1,398,000-1,744,700). Among men, approximately 11.4%, 30.5%, and 19.8% of deaths due to cardiovascular diseases, cancer, and respiratory diseases, respectively, were attributable to tobacco smoking. Corresponding proportions for East Asian women were 3.7%, 4.6%, and 1.7%, respectively. The strongest association with tobacco smoking was found for lung cancer: a 3- to 4-fold elevated risk, accounting for 60.5% and 16.7% of lung cancer deaths, respectively, in Asian men and East Asian women aged ≥45 y. CONCLUSIONS:Tobacco smoking is associated with a substantially elevated risk of mortality, accounting for approximately 2 million deaths in adults aged ≥45 y throughout Asia in 2004. It is likely that smoking-related deaths in Asia will continue to rise over the next few decades if no effective smoking control programs are implemented. Please see later in the article for the Editors' Summary.
    Date: 2014-04-22
    Relation: PLoS Medicine. 2014 Apr 22;11(4):Article number e1001631.
    Link to: http://dx.doi.org/10.1371/journal.pmed.1001631
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1549-1277&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335465800016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84900415399
    Appears in Collections:[Shao-Yuan Chuang] Periodical Articles

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