國家衛生研究院 NHRI:Item 3990099045/8008
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8008


    Title: Oestrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells
    Authors: Huang, TS;Chen, YJ;Chou, TY;Chen, CY;Li, HY;Huang, BS;Tsai, HW;Lan, HY;Chang, CH;Twu, NF;Yen, MS;Wang, PH;Chao, KC;Lee, CC;Yang, MH
    Contributors: National Institute of Cancer Research
    Abstract: Adenomyosis is an oestrogen-dependent disease characterized by the invasion of endometrial epithelial cells into the myometrium of uterus, and angiogenesis is thought to be required for the implantation of endometrial glandular tissues during the adenomyotic pathogenesis. In this study, we demonstrate that compared with eutopic endometria, adenomyotic lesions exhibited increased vascularity as detected by sonography. Microscopically, the lesions also exhibited an oestrogen-associated elevation of microvascular density and VEGF expression in endometrial epithelial cells. We previously reported that oestrogen-induced Slug expression was critical for endometrial epithelial–mesenchymal transition and development of adenomyosis. Our present studies demonstrated that estradiol (E2) elicited a Slug-VEGF axis in endometrial epithelial cells, and also induced pro-angiogenic activity in vascular endothelial cells. The antagonizing agents against E2 or VEGF suppressed endothelial cells migration and tubal formation. Animal experiments furthermore confirmed that blockage of E2 or VEGF was efficient to attenuate the implantation of adenomyotic lesions. These results highlight the importance of oestrogen-induced angiogenesis in adenomyosis development and provide a potential strategy for treating adenomyosis through intercepting the E2-Slug-VEGF pathway.
    Date: 2014-07
    Relation: Journal of Cellular and Molecular Medicine. 2014 Jul;18(7):1358-1371.
    Link to: http://dx.doi.org/10.1111/jcmm.12300
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1582-1838&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000340413500012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905036860
    Appears in Collections:[Tze-Sing Huang] Periodical Articles

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