國家衛生研究院 NHRI:Item 3990099045/7998
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7998


    Title: Pharmacological profiles of oligomerized mu-opioid receptors
    Other Titles: Pharmacological profiles of oligomerized μ-opioid receptors
    Authors: Lee, CW;Ho, IK
    Contributors: Center for Neuropsychiatric Research
    Abstract: Opioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: mu-, delta-, kappa-opioid and opioid receptor-like 1 receptors. Bivalent ligands targeted to the oligomerized opioid receptors might be the key to developing analgesics without undesired side effects and obtaining effective treatment for opioid addicts. In this review we will update the biological effects of mu-opioids on homo- or hetero-oligomerized mu-opioid receptor and discuss potential mechanisms through which bivalent ligands exert beneficial effects, including adenylate cyclase regulation and receptor-mediated signaling pathways.
    Date: 2013-10-11
    Relation: Cells. 2013 Oct 11;2(4):689-714.
    Link to: http://dx.doi.org/10.3390/cells2040689
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2073-4409&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84947425910
    Appears in Collections:[Ing-Kang Ho(2006-2011)] Periodical Articles

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