國家衛生研究院 NHRI:Item 3990099045/7952
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    题名: HOXC6 overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma
    作者: Win, KT;Li, CF
    贡献者: National Institute of Cancer Research
    摘要: Background: Though the advances in diagnostic imaging and treatment modalities have achieved better locoregional control of nasopharyngeal carcinoma (NPC), it appears less satisfactory in fi nal treatment outcomes. Through data mining from public domain, homeobox C6 (HOXC6) was fi rst identifi ed as a differentially upregulated gene associated with regulation of transcription from RNA polymerase II promoter in the transcriptome of NPCs. HOXC6 belongs to a member of the homeobox family, deregulated expression of which has been observed in many tumor types including leukemia, breast, lung, and prostate cancer. Since its signifi cant has not been systematically investigated in NPC, we therefore explored the signifi cance of HOXC6 immunoexpression status and its association with cell proliferation index Ki-67 in a large cohort of NPC patients.Design: HOXC6 and Ki-67 immunohistochemistry was retrospectively performed and analyzed using H-score method for biopsy specimens from 124 NPC patients who received standard treatment without distant metastasis at initial diagnosis. Those cases with H-score larger than the median value were defi ned as HOXC6 overexpression. The results were correlated with the clinicopathological variables, disease-specifi c survival (DSS) and metastasis-free survival (MeFS).Results: HOXC6 overexpression was signifi cantly positively associated with Ki-67 expression, and signifi cantly associated with increments of tumor stage (p=0.024), advanced nodal status (p<0.001) and American Joint Committee on Cancer (AJCC) stage (p=0.002). Its overexpression also correlated with worse prognosis in terms of DSS (p=0.0008), MeFS (p=0.0047) univariately. In multivariate comparisons, HOXC6 overexpression still remained prognostically independent to portend worse DSS (p=0.015, hazard ratio=1.988) and MeFS (p=0.036, hazard ratio=1.899), together with advanced AJCC stages III-IV (p=0.024, DSS; p=0.043, MeFS).Conclusions: HOXC6 expression is upregulated in a subset of NPCs and its increased immunoexpression signifi cantly correlated with advanced stages and tumor aggressiveness, justifying the potentiality of HOXC6 as a prognostic biomarker and a novel therapeutic target of NPC.
    日期: 2014-02
    關聯: Laboratory Investigation. 2014 Feb;94(S1):331A.
    Link to: http://dx.doi.org/10.1038/labinvest.2014.25
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0023-6837&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000331155801583
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