國家衛生研究院 NHRI:Item 3990099045/7925
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    题名: Programmed death-1 ligand mrna levels may predict survival and relapse in non-small cell lung cancer
    作者: Wu, YH;Lee, MC;Chen, CY;Lee, H
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Background: Programmed death-1 ligand (PD-L) involved in PD-1/PD-L1 pathway has been shown to associate with tumor progression via suppression of T-cell immunity. However, the prognostic value of PD-L1 in non-small cell lung cancer (NSCLC) remains unclear, especially in human papillomavirus (HPV)-infected lung cancer. Methods: Two hundred and twenty one lung tumors surgically resected from NSCLC patients were enrolled to determine PD-L1 mRNA expression by real-time RT-PCR. HPV 16/18 E6 expression in lung tumors was examined by immunohistochemistry. The role of E6 on PD-L1 expression was examined by E6-knockdown and E-overexpression in HPV16 E6-positive lung cancer cells. Kaplain-Meier and Multivariate Cox regression analysis were used to verify whether PD-L1 mRNA levels may predict overall survival (OS) and relapse free survival (RFS) in NSCLC, especially in patients with E6-positive tumors. Results: PD-L1 mRNA levels in E6-positive TL-1 and TL-2 cells were remarkably higher than E6-negative A549, H23, H1355, TL-4, TL-5, TL-6 lung cancer cells. PD-L1 expression was decreased in E6-knockdown TL-1 and TL-2, and increased in E6-overexpression A549 and TL-4 cells compared with their control cells. Patients with low PD-L1 mRNA levels had poorer OS and RFS than those with high PD-L1 mRNA levels. Among patients with high PD-L1 mRNA levels, the hazard ratio (HR) of E6-positive patients was elevated to 1.89 (95% CI, 1.17-2.66, P = 0.003) compared with that of E6-negative patients (HR, 1.31, 95% CI, 1.07-1.58, P = 0.007). Conclusion: PD-L1 mRNA levels may predict survival and relapse in NSCLC. We suggest that PD-L1 may be a potential immunotherapeutic target in NSCLC, especially in patients with HPV infection.
    日期: 2011-06
    關聯: Journal of Thoracic Oncology. 2011 Jun;6(6):S667-S668.
    Link to: http://dx.doi.org/10.1097/01.JTO.0000399289.73317.3d
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1556-0864&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000208855803075
    显示于类别:[李輝(2009-2011)] 會議論文/會議摘要

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