國家衛生研究院 NHRI:Item 3990099045/7867
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7867


    Title: Dialysis-requiring acute kidney injury increases risk of long-term malignancy: A population-based study
    Authors: Chao, CT;Wang, CY;Lai, CF;Huang, TM;Chen, YY;Kao, TW;Chu, TS;Chang, CH;Wu, VC;Ko, WJ;Chen, L;Wu, KD
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Background: Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been studied before. Methods: We conducted a population study based on the Taiwan National Health Insurance database, using 1,000,000 representative database during 2000-2008. All patients' survival to discharge from index hospitalization with recovery from dialysis-requiring AKI were identified (recovery group), and matched with those without recovery and those without AKI, at a 1:1:1 ratio. Results: We identified 625 individuals more than 18 years old [352 male (56.5 %); mean age, 63.3 years] in recovery group and matched 625 individuals in each group. During a mean followed-up of 3.7 years, the incidences of new-onset malignancy were 4.2, 2.9, and 2.6 per 100 person-year among the non-recovery, the recovery, and the non-AKI group, respectively. After adjustment, the recovery group was more likely to develop long-term de novo malignancy than those without AKI [hazard ratio (HR) 1.44, 95 % confidence interval (CI) 1.02-2.03; p = 0.04], while less likely than those who did not recover (HR 0.66, 95 % CI 0.45-0.98; p = 0.04). Conclusions: Dialysis-requiring AKI can post a long-term risk of de novo malignancy for those who survive from the initial insult. Even patients who have recovered from dialysis still carry a significantly higher possibility of developing malignancy than those without AKI episode.
    Date: 2014-04
    Relation: Journal of Cancer Research and Clinical Oncology. 2014 Apr;140(4):613-621.
    Link to: http://dx.doi.org/10.1007/s00432-014-1600-z
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0171-5216&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000332875700010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84899491777
    Appears in Collections:[Li-Kwang Chen] Periodical Articles

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