國家衛生研究院 NHRI:Item 3990099045/7858
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    题名: Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones
    作者: Chang, CY;Chuang, HY;Lee, HY;Yeh, TK;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
    贡献者: National Institute of Cancer Research;Institute of Biotechnology and Pharmaceutical Research
    摘要: 2-Hydroxy-3,4,5-trimethoxybenzophenones (8-16) manifest pseudo-ring formation involving intramolecular hydrogen bonding of the 2-OH and the carbonyl group. Among the synthetic products described in this report, (3-hydroxy-4-methoxyphenyl)(2-hydroxy-3,4,5- trimethoxyphenyl)-methanone (14) and (3-amino-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxy- phenyl)methanone (16) exhibit significant antiproliferative activity against KB cells with IC50 values of 11.1 and 11.3 nM, respectively. These two compounds also displayed tubulin affinity comparable to that of combretastatin A-4. In studies with human umbilical vein endothelial cells, compounds 14 and 16 revealed concentration-dependent vascular-disrupting properties. The results support the rationale of the pseudo-ring concept and suggest further investigation of A-ring modification in these benzophenones.
    日期: 2014-04
    關聯: European Journal of Medicinal Chemistry. 2014 Apr 22;77(2):306-314.
    Link to: http://dx.doi.org/10.1016/j.ejmech.2014.02.061
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0223-5234&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335874800034
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896536146
    显示于类别:[張俊彥] 期刊論文
    [郭靜娟] 期刊論文
    [葉燈光] 期刊論文

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