國家衛生研究院 NHRI:Item 3990099045/7766
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    题名: Possible race and gender divergence in association of genetic variations with plasma von Willebrand Factor: A study of ARIC and 1000 genome cohorts
    作者: Zhou, Z;Yu, F;Buchanan, A;Fu, Y;Campos, M;Wu, KK;Chambless, LE;Folsom, AR;Boerwinkle, E;Dong, JF
    贡献者: Institute of Cellular and Systems Medicine
    摘要: The synthesis, secretion and clearance of von Willebrand factor (VWF) are regulated by genetic variations in coding and promoter regions of the VWF gene. We have previously identified 19 single nucleotide polymorphisms (SNPs), primarily in introns that are associated with VWF antigen levels in subjects of European descent. In this study, we conducted race by gender analyses to compare the association of VWF SNPs with VWF antigen among 10,434 healthy Americans of European (EA) or African (AA) descent from the Atherosclerosis Risk in Communities (ARIC) study. Among 75 SNPs analyzed, 13 and 10 SNPs were associated with VWF antigen levels in EA male and EA female subjects, respectively. However, only one SNP (RS1063857) was significantly associated with VWF antigen in AA females and none was in AA males. Haplotype analysis of the ARIC samples and studying racial diversities in the VWF gene from the 1000 genomes database suggest a greater degree of variations in the VWF gene in AA subjects as compared to EA subjects. Together, these data suggest potential race and gender divergence in regulating VWF expression by genetic variations.
    日期: 2014-01-17
    關聯: PLoS ONE. 2014 Jan 17;9(1):Article number e84810.
    Link to: http://dx.doi.org/10.1371/journal.pone.0084810
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000330237000016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84898459717
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