國家衛生研究院 NHRI:Item 3990099045/7755
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    题名: Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans
    作者: Liao, BY;Chang, AYF
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: BACKGROUND:During eukaryotic genome evolution, tandem gene duplication is the most frequent event giving rise to clustered gene families. However, how expression divergence between tandemly duplicated genes has emerged and maintained remain unclear. In particular, it is unknown if epigenetic regulators have been involved in the process.RESULTS:We demonstrate that CCCTC-binding factor (CTCF), the master epigenetic regulator and the only known insulator protein in humans, has played a predominant role in generating divergence in both expression profiles and expression levels between adjacent paralogs in the human genome. This phenomenon was not observed for non-paralogous adjacent genes. After tandem duplication events, CTCF-binding sites gradually accumulate between paralogs. This trend was more prominent for genes involved in particular functions.CONCLUSIONS:The accumulation of CTCF-binding sites drives expression divergence of tandemly duplicated genes. This process is likely targeted by natural selection. Our study reveals the importance of CTCF to the evolution of animal diversity and complexity.
    日期: 2014-01-24
    關聯: BMC Genomics. 2014 Jan 24;15(Suppl. 1):Article number S8.
    Link to: http://dx.doi.org/10.1186/1471-2164-15-s1-s8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1471-2164&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000330693900008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84945931931
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