國家衛生研究院 NHRI:Item 3990099045/7739
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    题名: Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy
    作者: Cheng, Y;Morshed, R;Cheng, SH;Tobias, A;Auffinger, B;Wainwright, DA;Zhang, L;Yunis, C;Han, Y;Chen, CT;Lo, LW;Aboody, KS;Ahmed, AU;Lesniak, MS
    贡献者: Division of Medical Engineering Research
    摘要: A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.
    日期: 2013-12
    關聯: Small. 2013 Dec;9(24):4123-4129.
    Link to: http://dx.doi.org/10.1002/smll.201301111
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1613-6810&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000328453300005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84890471760
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