Primary localized cutaneous amyloidosis (PLCA [OMIM 105250]) is a relatively common itchy skin disorder in South America and Southeast Asia.1-2 The precise pathogenesis of PLCA is unclear, but it is considered to be multifactorial, involving both genetic and environmental factors. Most PLCA cases are sporadic. In Southeast Asia, familial PLCA (FPLCA) is also prevalent.1 Genome-wide linkage analyses have revealed that disease susceptibility loci of a significant portion of collected pedigrees are mapped to chromosome 5p13.1-q11.2.3,4 Subsequent investigation has identified missense mutations in the oncostatin M receptor (OSMR) or interleukin-31 receptor A (IL31RA) genes.4-9
Date:
2014-04
Relation:
British Journal of Dermatology. 2014 Apr;170(4):974-976.
