國家衛生研究院 NHRI:Item 3990099045/7672
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    题名: Survivin - biology and potential as a therapeutic target in oncology
    作者: Cheung, CHA;Huang, CC;Tsai, FY;Lee, JYC;Cheng, SM;Chang, YC;Huang, YC;Chen, SH;Chang, JY
    贡献者: National Institute of Cancer Research
    摘要: Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule. In this review, the complex expression regulations and post-translational modifications of survivin are discussed. This review also discusses how recent discoveries improve our understanding of survivin biology and also create opportunities for developing differential-functioned survivin-targeted therapy. Databases such as PubMed, Scopus (R) (Elsevier, New York, NY, USA), and SciFinder (R) (CAS, Columbus, OH, USA) were used to search for literature in the preparation of this review.
    日期: 2013-10-16
    關聯: Oncotargets and Therapy. 2013 Oct 16;6:1453-1462.
    Link to: http://dx.doi.org/10.2147/ott.s33374
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1178-6930&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000325604300001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84886067499
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