 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12145/12927 (94%)
Visitors : 907659
Online Users : 951
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/7646
|
| Title: | A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent |
| Authors: | Chen, PL;Wu, CJ;Chen, CS;Tsai, PJ;Tang, HJ;Ko, WC |
| Contributors: | Division of Infectious Diseases |
| Abstract: | Aeromonas dhakensis, often phenotypically identified as A. hydrophila, is an important human pathogen. The present study aimed to compare the clinical and biological features of A. dhakensis and A. hydrophila isolates from human wounds. A total of 80 of Aeromonas wound isolates collected between January 2004 and April 2011 were analyzed. The species was identified by the DNA sequence matching of rpoD and gyrB (or rpoB if necessary). Most of the Aeromonas isolates were identified as A. dhakensis (37, 46.3%), and 13 (16.3%) as A. hydrophila. Both these two species alone can cause severe skin and soft-tissue infections. More A. dhakensis isolates were found in wounds exposed to environmental water (32.4% vs. 0%, P=0.042). More biofilm formation was noted among A. dhakensis isolates (mean OD570, 1.23±0.09 vs. 0.78±0.21, P=0.03). The minimal inhibitory concentrations of ceftriaxone, imipenem, and gentamicin for A. dhakensis isolates were higher (P values <0.0001, 0.04, and 0.01, respectively). The survival rates of Caenorhabditis elegans co-incubated by A. dhakensis from day 1 to day 3 were lower than those of worms infected with A. hydrophila in liquid toxicity assays (all P values <0.01). A. dhakensis isolates exhibited more cytotoxicity, as measured by the released leukocyte lactate dehydrogenase levels in human normal skin fibroblast cell lines (29.6±1.2% vs. 20.6±0.6%, P<0.0001). The cytotoxin gene ast was primarily present in A. hydrophila isolates (100% vs. 2.7%, P<0.0001). In summary, A. dhakensis is the predominant species among Aeromonas wound isolates, and more virulent than A. hydrophila. |
| Date: | 2014-07 |
| Relation: | Clinical Microbiology and Infection. 2014 Jul;20(7):O428-O434. |
| Link to: | http://dx.doi.org/10.1111/1469-0691.12456 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1198-743X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000340199000004 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905018680 |
| Appears in Collections: | [吳綺容] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| PB2013112603.pdf | | 184Kb | Adobe PDF | 613 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
