國家衛生研究院 NHRI:Item 3990099045/7575
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    题名: Sarcopenia variables cut-points, disability and falls in older adults- a pooled analysis
    作者: Wu, IC;Hsiung, CA;Wu, MS;Hsu, CC;Sarcopenia and Translational Aging Research in Taiwan (START)
    贡献者: Division of Geriatric Research;Division of Biostatistics and Bioinformatics
    摘要: Sarcopenia is becoming an urgent health issue in aging population. Operational efinitions have recently been proposed to facilitate prompt recognition of sarcopenia in clinical practice. However, evidence indicated that the proper cut-off points of sarcopenia variables for Asians may be different from Westerners. The purpose of this study is to determine sarcopenia variables cut-points for identifying elevated physical disability and falls risk in a large sample of older Taiwanese adults. We pooled the primary data from three major cohort studies in Taiwan, as part of the Sarcopenia and Translational Aging Research in Taiwan (START) project. Data on 1770 adults aged ? 65 years (mean age = 74 years) were analyzed. Bioelectrical impedance analysis was used to measure appendicular skeletal muscle mass. Relative skeletal muscle was calculated as appendicular skeletal muscle mass (kg) divided by weight (kg). Gait speed was determined by measuring usual-paced walking velocity. The presence of difficulty in any ADL(eating, transfer, toilet use, bathing,mobility, dressing, bowels/bladder) or IADL (shopping, housekeeping, handling finances, food preparation, transportation, using telephone, laundry, medications), or falls in the past year was also determined. Receiver operating characteristics analysis was used to develop muscle mass cut-points (sex-specific) and gait speed cut-points (sex-and height-specific) associated with physical disability and falls. Multivariate analyses adjusted for sociodemographic variables, lifestyle factors and various medical conditions were used to compare odds for physical disability and falls for individuals whose sarcopenia variables fell above and below these cut-points. The skeletal muscle cut-points denoting high risk were 28.76 % for men and 21.76 % for women. The gait speed cut-points denoting high risk were 0.7 m/s for men with height ≦ 163 cm, 0.8m/s for men with height >163 cm, 0.6 m/s for women with height ≦ 152 cm and 0.7 m/s for women with height >152 cm. Compared with those with low-risk muscle mass values, participants with high-risk muscle mass values had higher odds for physical disability and falls (adjusted OR, 2.02 in men [95% CI, 1.17-3.49] and 1.91 in women [95 % CI, 1.09-3.35]). Compared with those with low-risk gait speed values, participants with high-risk gait speed values had higher odds for physical disability and falls (adjusted OR, 4.66 in men with height ≦ 163 cm [95% CI, 2.42-8.97], 3.87 in men with height >163 cm [95% CI, 1.52-9.89], 9.40 in women with height ≦ 152 cm [95% CI, 4.62-19.14] and 5.14 in women with height >152 cm [95% CI, 2.48-10.63]). Low muscle mass and gait speed defined using the cut-off points were independently associated with disability and falls in older adults. Further studies are needed for future applications of these cut-points in sarcopenia diagnosis and treatment.
    日期: 2013-10
    關聯: 2013年公衛聯合年會. 2013 Oct:70.
    Link to: http://www.publichealth.org.tw/upload/files/2013TPHAAnnual.pdf
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