國家衛生研究院 NHRI:Item 3990099045/7570
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    题名: Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis
    作者: Wang, WC;Hsieh, HP
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Pyrimidine derivatives bearing amino substituents have been of multifold biological and pharmacological interest. In order to speed up lead identification for drug discovery, the application of high throughput parallel synthesis (HTPS) has become an important target. It is also well known that SNAr reaction has become a useful and efficient synthetic protocol. Herein, a focused library of pyrimidine derivatives was rapidly synthesized in parallel reactor via SNAr displacement and progress of all reactions was monitored by UPLC and LCMS. All library compounds were further screened for kinase activities leading to the identification of interest hit.
    日期: 2013-04-07
    關聯: Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 298-MEDI
    Link to: http://abstracts.acs.org/chem/245nm/program/view.php?pub_num=298&par=MEDI
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000324303602317
    显示于类别:[謝興邦] 會議論文/會議摘要
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