國家衛生研究院 NHRI:Item 3990099045/7567
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    题名: PUPPI: A pathway analysis method using protein-protein interaction network for case-control data
    作者: Chung, RH
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: The development of statistical pathway analysis methods has focused on testing individual main effects of genes in a pathway on disease. However, gene-gene interactions can also play an important role in complex disease etiology. We developed a pathway analysis method based on a protein-protein interaction network to account for gene-gene interactions in a pathway. We used simulations to evaluate the type I error and power for the method. Our simulation results suggest that the method has correct type I error rates, and can be powerful in the identification of the effects of gene-gene interaction in pathways under different scenarios. The method has been implemented into an efficient software package with C++.
    日期: 2013-04
    關聯: 2013 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). 2013 Apr:238-241.
    Link to: http://dx.doi.org/10.1109/cibcb.2013.6595415
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000333898800035
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84885085502
    显示于类别:[鍾仁華] 會議論文/會議摘要

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